Welcome.
If you have found your way to this guide, something is probably wrong. Maybe you are pregnant and sicker than anyone told you was possible. Maybe you are a partner watching someone you love disappear into nausea and exhaustion. Maybe you are a parent, a friend, or a nurse looking for words that actually help.
Hyperemesis Gravidarum affects an estimated 0.3 to 3 percent of pregnancies. That may sound small until you do the math: in the United States alone, tens of thousands of women experience HG every year. Behind each of those numbers is a woman who likely felt, at some point, that no one understood what she was going through.
Many women with HG describe the same painful pattern: they knew something was wrong, but the people around them, and sometimes even their care providers, told them it was just morning sickness. If that has happened to you, please hear this clearly: severe, persistent vomiting in pregnancy is not normal, it is not a character flaw, and it deserves medical attention. The research community now understands HG as a biologically driven condition. Being sick is not your fault.
THON built the HG Care Hub because the gap between what science knows about HG and what patients are told about HG is too wide. Clinical guidelines support early treatment. Genetic research has identified biological causes. Advocacy organizations have documented the real toll of this condition for decades. And yet women still routinely wait too long for care, are dismissed too easily, and are sent home without the information they need.
This guide exists to put that information directly into your hands, in language you can absorb even on your worst day, so that no woman has to become an expert in HG the hard way, alone.
This guide is designed to be used, not just read. You can read it front to back, or you can go straight to what you need today:
Throughout the Care Hub you will see callout boxes: Clinical Pearls translate medical insight into practical understanding, Key Takeaways summarize each chapter, and emergency boxes tell you when to act immediately.
Preparing for an appointment can feel overwhelming, especially when you are not feeling well. These conversation starters can help you have a more informed discussion with your healthcare provider. Depending on what you learn together, THON can help guide you to additional resources throughout your HG journey.
An accurate diagnosis is one of the most important first steps toward appropriate treatment and preventing complications. Naming the condition is what allows a care plan to begin.
Knowing the threshold in advance removes the hardest decision from the hardest moment. Most women delay care because no one told them clearly where the line is.
Care decisions in HG are driven by trends rather than single days. Agreeing on what gets measured, and how often, is what makes escalation possible before you become severely unwell.
HG is managed in steps. Understanding the sequence in advance means that if one treatment stops working, you already know it is expected — not a sign that you are failing.
HG does not keep office hours. A named contact and a clear route to help is often the difference between early treatment and an emergency admission.
Some practices have rapid hydration pathways that avoid an emergency department entirely. Asking is often the only way to find out that one exists.
For too long, women with Hyperemesis Gravidarum were told it was ordinary morning sickness — left to carry the physical, emotional, nutritional, and financial weight of it, and to coordinate their own scattered care, through one of pregnancy's most debilitating conditions. HG did not only expose a gap in one diagnosis. It exposed the fragmentation running through all of women's healthcare.
THON was built so that women facing HG — and, in time, every woman — would meet coordinated expertise, unbroken continuity, and genuine compassion instead. This is where the mission began. It is not where it ends.
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